Abbreviations
PBC, primary biliary cholangitis; PPAR α/δ, peroxisome proliferator-activated receptor alpha + delta
Reference
- IQIRVO® (elafibranor) Summary of product characteristics (SmPC). 2024.
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Mechanism of action
While the exact mechanism by which IQIRVO exerts its therapeutic effects in patients with PBC is not fully understood, it is thought that PPAR-α and PPAR-δ are key regulators of bile acid homeostasis, inflammation and fibrosis.
PBC, primary biliary cholangitis; PPAR α/δ, peroxisome proliferator-activated receptor alpha + delta